Adams Waldorf, K. M. & McAdams, R. M. Influence of infection during pregnancy on fetal development. Reproduction 146, R151–R162 (2013).
Al-Haddad, B. J. S. et al. Long-term risk of neuropsychiatric disease after exposure to infection in utero. JAMA Psychiatry 76, 594–602 (2019).
Al-Haddad, B. J. S. et al. The fetal origins of mental illness. Am. J. Obstet. Gynecol. 221, 549–562 (2019).
Bilbo, S. D., Block, C. L., Bolton, J. L., Hanamsagar, R. & Tran, P. K. Beyond infection—maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders. Exp. Neurol. 299(Pt A), 241–251 (2018).
Gregor, M. F. & Hotamisligil, G. S. Inflammatory mechanisms in obesity. Annu Rev. Immunol. 29, 415–445 (2011).
Wilson, R. M. & Messaoudi, I. The impact of maternal obesity during pregnancy on offspring immunity. Mol. Cell Endocrinol. 418(Pt 2), 134–142 (2015).
Cordeiro, C. N., Tsimis, M. & Burd, I. Infections and brain development. Obstet. Gynecol. Surv. 70, 644–655 (2015).
Yockey, L. J., Lucas, C. & Iwasaki, A. Contributions of maternal and fetal antiviral immunity in congenital disease. Science 368, 608–612 (2020).
Zerbo, O. et al. Maternal infection during pregnancy and autism spectrum disorders. J. Autism Dev. Disord. 45, 4015–4025 (2015).
Mednick, S. A. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch. Gen. Psychiatry 45, 189 (1988).
Nunez, J. L., Alt, J. J. & McCarthy, M. M. A novel model for prenatal brain damage. II. Long-term deficits in hippocampal cell number and hippocampal-dependent behavior following neonatal GABAA receptor activation. Exp. Neurol. 181, 270–280 (2003).
Nakai, Y. et al. Apoptosis and microglial activation in influenza encephalopathy. Acta Neuropathol. 105, 233–239 (2003).
Smolders, S., Notter, T., Smolders, S. M. T., Rigo, J. M. & Brone, B. Controversies and prospects about microglia in maternal immune activationmodels for neurodevelopmental disorders. Brain Behav. Immun. 73, 51–65 (2018).
Fernandez de Cossio, L., Guzman, A., van der Veldt, S. & Luheshi, G. N. Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring. Brain Behav. Immun. 63, 88–98 (2017).
Zhao, Q. et al. Maternal immune activation-induced PPARgamma-dependent dysfunction of microglia associated with neurogenic impairment and aberrant postnatal behaviors in offspring. Neurobiol. Dis. 125, 1–13 (2019).
Edlow, A. G. et al. Placental macrophages, a window into fetal microglial function in maternal obesity. Int. J. Dev. Neurosci. 77, 60–68 (2019).
Lenz, K. M. & McCarthy, M. M. A starring role for microglia in brain sex differences. Neuroscientist 21, 306–321 (2015).
Bilimoria, P. M. & Stevens, B. Microglia function during brain development, new insights from animal models. Brain Res. 1617, 7–17 (2015).
Paolicelli, R. C. et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333, 1456–1458 (2011).
Schafer, D. P. et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691–705 (2012).
Sierra, A. et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 7, 483–495 (2010).
Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841–845 (2010).
Gomez Perdiguero, E. et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547–551 (2015).
Ginhoux, F. & Prinz, M. Origin of microglia: current concepts and past controversies. Cold Spring Harb. Perspect. Biol. 7, a020537 (2015).
Gomez Perdiguero, E., Schulz, C. & Geissmann, F. Development and homeostasis of “resident” myeloid cells: the case of the microglia. Glia 61, 112–120 (2013).
Haley, M. J., Brough, D., Quintin, J. & Allan, S. M. Microglial priming as trained immunity in the brain. Neuroscience 405, 47–54 (2019).
Merad, M. & Martin, J. C. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat. Rev. Immunol. 20, 355–362 (2020).
Sellgren, C. M. et al. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat. Neurosci. 22, 374–385 (2019).
Sellgren, C. M. et al. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol. Psychiatry 22, 170–177 (2017).
Baum, M. L. et al. CUB and Sushi Multiple Domains 1 (CSMD1) opposes the complement cascade in neural tissues. Preprint at bioRxiv, https://doi.org/10.1101/2020.09.11.291427 (2020).
Lui, H. et al. Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation. Cell 165, 921–935 (2016).
Sarn, N. et al. Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype. Mol. Psychiatry https://doi.org/10.1038/s41380-020-0681-0 (2020).
Boyum, A. Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. Suppl 5, 9–15 (1976).
Gray, E. G. & Whittaker, V. P. The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. J. Anat. 96, 79–88 (1962).
Kamat, P. K., Kalani, A. & Tyagi, N. Method and validation of synaptosomal preparation for isolation of synaptic membrane proteins from rat brain. MethodsX 1, 102–107 (2014).
Tenreiro, P. et al. Comparison of simple sucrose and percoll based methodologies for synaptosome enrichment. Anal. Biochem. 517, 1–8 (2017).
McQuin, C. et al. CellProfiler 3.0: next-generation image processing for biology. PLoS Biol. 16, e2005970 (2018).
Mohammadi, A., Esmaeilzadeh, E., Li, Y., Bosch, R. J. & Li, J. Z. SARS-CoV-2 detection in different respiratory sites: a systematic review and meta-analysis. EBioMedicine 59, 102903 (2020).
Bergdolt, L. & Dunaevsky, A. Brain changes in a maternal immune activation model of neurodevelopmental brain disorders. Prog. Neurobiol. 175, 1–19 (2019).
Careaga, M., Murai, T. & Bauman, M. D. Maternal immune activation and autism spectrum disorder: from rodents to nonhuman and human primates. Biol. Psychiatry 81, 391–401 (2017).
Haddad, F. L., Patel, S. V. & Schmid, S. Maternal immune activation by Poly I:C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia. Neurosci. Biobehav. Rev. 113, 546–567 (2020).
Ito, H. T., Smith, S. E., Hsiao, E. & Patterson, P. H. Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring. Brain Behav. Immun. 24, 930–941 (2010).
Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J. & Patterson, P. H. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav. Immun. 26, 607–616 (2012).
Brown, A. S. & Meyer, U. Maternal immune activation and neuropsychiatric illness: a translational research perspective. Am. J. Psychiatry 175, 1073–1083 (2018).
Conway, F. & Brown, A. S. Maternal immune activation and related factors in the risk of offspring psychiatric disorders. Front. Psychiatry 10, 430 (2019).
Missault, S. et al. The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model. Brain Behav. Immun. 42, 138–146 (2014).
Liu, J. et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine 55, 102763 (2020).
Mehta, P. et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395, 1033–1034 (2020).
Kotlyar, A. M. et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 224, 35–53.e3 (2021).
Flaherman, V. J. et al. Infant outcomes following maternal infection with SARS-CoV-2: first report from the PRIORITY Study. Clin. Infect. Dis. ciaa1411, https://doi.org/10.1093/cid/ciaa1411 (2020).
Vivanti, A. J. et al. Transplacental transmission of SARS-CoV-2 infection. Nat. Commun. 11, 3572 (2020).
Cai, Z., Pan, Z. L., Pang, Y., Evans, O. B. & Rhodes, P. G. Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr. Res. 47, 64–72 (2000).
Stevens, B. et al. The classical complement cascade mediates CNS synapse elimination. Cell 131, 1164–1178 (2007).
Urakubo, A., Jarskog, L. F., Lieberman, J. A. & Gilmore, J. H. Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, and fetal brain. Schizophr. Res. 47, 27–36 (2001).