T-cell replete haploidentical transplantation with reduced post-transplant cyclophosphamide in six children with infantile osteopetrosis
  • 1.

    Orchard PJ, Fasth AL, Le Rademacher J, He W, Boelens JJ, Horwitz EM, et al. Hematopoietic stem cell transplantation for infantile osteopetrosis. Blood. 2015;126:270–6.

    CAS  Article  Google Scholar 

  • 2.

    Chiesa R, Ruggeri A, Paviglianiti A, Zecca M, Gonzalez-Vicent M, Bordon V, et al. Outcomes after unrelated umbilical cord blood transplantation for children with steopetrosis. Biol Blood Marrow Transpl. 2016;22:1997–2002.

    Article  Google Scholar 

  • 3.

    McCurdy SR, Fuchs EJ. Comparable outcomes for hematologic malignancies after HLA-haploidentical transplantation with post transplantation cyclophosphamide and HLA-matched transplantation. Adv Hematol. 2015;2015:431923.

    Article  Google Scholar 

  • 4.

    Klein OR, Chen AR, Gamper C, Loeb D, Zambidis E, Llosa N, et al. Alternative-donor hematopoietic stem cell transplantation with post-transplantation cyclophosphamide for nonmalignant disorders. Biol Blood Marrow Transpl. 2016;22:895–901.

    CAS  Article  Google Scholar 

  • 5.

    Natsheh J, Drozdinsky G, Simanovsky N, Lamdan R, Erlich O, Gorelik N, et al. Improved outcomes of hematopoietic stem cell transplantation in patients with infantile malignant osteopetrosis using fludarabine-based conditioning. Pediatr Blood Cancer. 2016;63:535–40.

    CAS  Article  Google Scholar 

  • 6.

    Schulz AS, Classen CF, Mihatsch WA, Sigl-Kraetzig M, Wiesneth M, Debatin KM, et al. HLA-haploidentical blood progenitor cell transplantation in osteopetrosis. Blood. 2002;99:3458–60.

    CAS  Article  Google Scholar 

  • 7.

    Pronk CJ, Turkiewicz D, Dykes J, Toporski J. Transplantation of maternal haploidentical TcRαβ-depleted stem cells for malignant infantile osteopetrosis–optimal timing and rapid hematological recovery. Blood. 2014;124:5935.

    Article  Google Scholar 

  • 8.

    Porta F, Cavagnini S, Imberti L, Sottini A, Bolda F, Beghin A, et al. Partial depletion of TCR alpha/beta+/CD19+ cells in matched unrelated transplantation of three patients with osteopetrosis. Bone marrow Transpl. 2015;50:1583–5.

    CAS  Article  Google Scholar 

  • 9.

    Bahr TL, Lund T, Sando NM, Orchard PJ, Miller WP. Haploidentical transplantation with post-transplant cyclophosphamide following reduced-intensity conditioning for osteopetrosis: outcomes in three children. Bone Marrow Transpl. 2016;51:1546–8.

    CAS  Article  Google Scholar 

  • 10.

    Neven B, Diana JS, Castelle M, Magnani A, Rosain J, Touzot F, et al. Haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide for primary immunodeficiencies and inherited disorders in children. Biol Blood Marrow Transpl. 2019;25:1363–73.

    Article  Google Scholar 

  • 11.

    Yuan J, Pei R, Su W, Cao J, Lu Y. Meta-analysis of the actions of antithymocyte globulin in patients undergoing allogeneic hematopoietic cell transplantation. Oncotarget. 2017;8:10871–1082.

    Article  Google Scholar 

  • 12.

    Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG. Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression. J Clin Invest. 2019;129:2357–73.

    Article  Google Scholar 

  • 13.

    Ayas M, Siddiqui K, Al-Jefri A, Al-Ahmari A, Ghemlas I, Al-Saedi H, et al. Successful outcome in patients with Fanconi Anemia undergoing T cell-replete mismatched related donor hematopoietic cell transplantation using reduced-dose cyclophosphamide post-transplantation. Biol Blood Marrow Transpl. 2019;25:2217–21.

    CAS  Article  Google Scholar 

  • Read original article here.